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Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3, Pages 269-279 doi: 10.1007/s11684-018-0621-4

Abstract: as a frontline lymphoid organ with complex immunological features such as liver immunity and liver toleranceLiver tolerance plays an important role in liver diseases including acute inflammation, chronic infectionNK cell activation, well known for its role in the immune surveillance against tumor and pathogen-infectedUnder the setting of liver diseases, NK cells are of great importance for stimulating or inhibiting immuneresponses, leading to either immune activation or immune tolerance.

Keywords： natural killer cell phenotype immune activation immune tolerance liver diseases

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Diverse Roles of Immune Cells in Transplant Rejection and Immune Tolerance Review

Xiaojie Gan, Jian Gu, Zheng Ju, Ling Lu

Engineering 2022, Volume 10, Issue 3, Pages 44-56 doi: 10.1016/j.eng.2021.03.029

Abstract:

Organ transplant rejection (OTR) is a complex immune reaction involvingHowever, immunosuppressive agents negatively impact the immune system of the patients, causing them toTherefore, a thorough understanding of the mechanisms involved in immune tolerance and immune rejectionThis article reviews the role of immune cells in OTR and organ transplant tolerance (OTT), including

Keywords： Immune cells Innate immune cells Adaptive immune cells Organ transplant Immune tolerance

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Functional tolerance theory in incremental growth design

YANG Bo, ZE Xiangbo, YANG Tao

Frontiers of Mechanical Engineering 2007, Volume 2, Issue 3, Pages 336-343 doi: 10.1007/s11465-007-0059-x

Abstract: The evolutionary tolerance design strategy and its characteristics are studied on the basis of automationrequirement to geometry constraints between parts, and finally to dimension constraints, a functional toleranceA mathematical model with a correlated sensitivity function between cost and the tolerance is createdthe usage cost, and the depreciation cost of the product are regarded as control constraints of the toleranceThus, allocation of the dimension tolerance as the function and cost over the whole lifetime of the product

Keywords： successful transformation mathematical automation technology tolerance allocation minimum

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Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

Frontiers of Medicine 2021, Volume 15, Issue 1, Pages 33-42 doi: 10.1007/s11684-019-0735-3

Abstract: Immunotherapy has recently led to a paradigm shift in cancer therapy, in which immune checkpoint inhibitorsnon-specific activation of effector T cells, ICIs are remarkably associated with a substantial risk of immune-related

Keywords： cancer immunotherapy immune checkpoint inhibitors immune-related adverse events review

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Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges

Tangchun Wu

Frontiers of Medicine 2020, Volume 14, Issue 6, Pages 816-819 doi: 10.1007/s11684-020-0823-4

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Heterogeneity of the tumor immune microenvironment and clinical interventions

Frontiers of Medicine 2023, Volume 17, Issue 4, Pages 617-648 doi: 10.1007/s11684-023-1015-9

Abstract: Heterogeneity of the tumor immune microenvironment and clinical interventions

Keywords： Heterogeneity tumor immune

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Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Frontiers of Medicine 2018, Volume 12, Issue 2, Pages 229-235 doi: 10.1007/s11684-017-0581-0

Abstract: MSI-H status due to dMMR and characterized by increased neoantigen load, which elicits intense host immune

Keywords： molecular classification precision medicine pembrolizumab PD-1/PD-L1 MSI-H

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TiO supported IrO for anode reversal tolerance in proton exchange membrane fuel cell

Frontiers in Energy 2022, Volume 16, Issue 5, Pages 852-861 doi: 10.1007/s11708-021-0811-7

Abstract: longer reversal time (530 min) than IrO_x (75 min), showing an excellent reversal toleranceO₇ with a high dispersity has a great potential to the application on the reversal tolerance

Keywords： proton exchange membrane fuel cell (PEMFC) fuel starvation cell reverse reversal tolerance anode

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APPLE SUMO E3 LIGASE MDSIZ1 NEGATIVELY REGULATES DROUGHT TOLERANCE

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 2,

Abstract: Here, we demonstrate that MdSIZ1 in apple has a negative relationship with drought tolerance

Keywords： apple / drought tolerance / gene expression / MdSIZ1

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Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected

Xinghua Gao, Hongduo Chen

Frontiers of Medicine 2014, Volume 8, Issue 1, Pages 1-5 doi: 10.1007/s11684-014-0309-3

Abstract: instance, fever-range temperature (39β°C to 40β°C) can modulate the activities of immuneCytotoxic temperature (>43β°C) can create an antigen source to induce an anti-tumor immune

Keywords： hyperthermia HPV immune response virus tumor

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SARS-CoV-2 variants, immune escape, and countermeasures

Frontiers of Medicine 2022, Volume 16, Issue 2, Pages 196-207 doi: 10.1007/s11684-021-0906-x

Abstract: Although many countries have promoted roll-out vaccination, the immune barrier has not yet been fully

Keywords： SARS-CoV-2 COVID-19 vaccine immune escape breakthrough prevention

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Multi-target combinatory strategy to overcome tumor immune escape

Frontiers of Medicine 2022, Volume 16, Issue 2, Pages 208-215 doi: 10.1007/s11684-022-0922-5

Abstract: Immune therapy has become the fourth approach after surgery, chemotherapy, and radiotherapy in cancerMany immune checkpoints were identified in the last decade since ipilimumab, which is the first immuneHowever, fewer people are benefitting from immune checkpoint inhibitor treatment in solid cancers.Along with the characterization of more immune checkpoints, the combinatory treatment of multi-immuneIn this work, the author focuses on the combination therapy of multiple immune checkpoints (does not

Keywords： immune checkpoints multi-target immune escape immune-related adverse events combination therapy

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Estimating the number of Chinese cancer patients eligible for and benefit from immune checkpoint inhibitors

Frontiers of Medicine 2022, Volume 16, Issue 5, Pages 773-783 doi: 10.1007/s11684-021-0902-1

Abstract: The total number of cancer patients who are eligible for and will benefit from immune checkpoint inhibitorspatients with eligibility and response to ICIs based on the 2015 Chinese cancer statistics and the immune

Keywords： benefit China eligibility immune checkpoint inhibitor public health

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A Robust Tolerance Design Method Based on Fuzzy Quality Loss

CAO Yan-long, MAO Jian, YANG Jiang-xin, WU Zhao-tong, WU Li-qun

Frontiers of Mechanical Engineering 2006, Volume 1, Issue 1, Pages 101-105 doi: 10.1007/s11465-005-0010-y

Abstract:

The traditional tolerance design model ignores the impact of noise factor, so that the design mayBased on the analysis of fuzzy factors in tolerance design and the limitations of the traditional TaguchiA robust tolerance design model using a fuzzy quality loss function was proposed.

Keywords： impact function robust tolerance suitable quality

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Innate immune responses in RNA viral infection

Qian Xu, Yuting Tang, Gang Huang

Frontiers of Medicine 2021, Volume 15, Issue 3, Pages 333-346 doi: 10.1007/s11684-020-0776-7

Abstract: Upon viral invasion, the innate immune system responds rapidly and plays a key role in activating theadaptive immune system.In the innate immune system, the interactions between pathogen-associated molecular patterns and hostMacrophages, dendritic cells, and natural killer cells are the principal innate immune components thatThis knowledge provides an enhanced understanding of the innate immune response to RNA viral infections

Keywords： innate immune viral infection intercellular signaling metabolic changes epigenetic changes